The effect of sarpogrelate on in-stent restenosis after percutaneous transluminal angioplasty in peripheral arterial disease
LIU Dan, CHEN Zhong, ZHAI Meng-yao, HE Nan, TANG Xiao-bin, ZHANG Xue-ning, WU Qing-hua
Published 2012-11-25
Cite as Chin J Gen Surg, 2012,27(11): 896-899. DOI: 10.3760/cma.j.issn.1007-631x.2012.11.012
Abstract
Objective To evaluate the impact of sarpogrelate on the in-stent restenosis (ISR) after percutaneous transluminal angioplasty (PTA) in peripheral arterial diseases (PAD).Methods PAD patients who had PTA for the first time were divided into two groups receiving respectively clopidogrel and aspirin (clopidogrel group) or sarpogrelate and aspirin (sarpogrelate group).Vascular ultrasonography was performed at 6 months after PTA in all patients to evaluate the degree of ISR.Results 62 patients finished the follow-up visits as required.The in-stent restenosis in the sarpogrelate group and clopidogrel group was 7.0% vs.18.1% (P =0.036),the peak systolic velocity ratio was 1.34 vs.2.08 (P =0.010) and the cases of ISR was 1 vs.10 (P =0.005) respectively.No patients reported serious adverse events.Conclusions Sarpogrelate combined with aspirin is safe and effective.Compare with clopidogrel and aspirin,sarpogrelate and aspirin can significantly reduce the rate of ISR after PTA and the intimal proliferation in the stent.
Key words:
Arterial occlusive diseases; Stents; In-stent restenosis; Sarpogrelate hydrochloride
Contributor Information
LIU Dan
Department of Vascular Surgery, Beijing Anzhen Hospital of the Capital University of Medical Sciences, Beijing 100029, China
CHEN Zhong
Department of Vascular Surgery, Beijing Anzhen Hospital of the Capital University of Medical Sciences, Beijing 100029, China
ZHAI Meng-yao
Department of Vascular Surgery, Beijing Anzhen Hospital of the Capital University of Medical Sciences, Beijing 100029, China
HE Nan
Department of Vascular Surgery, Beijing Anzhen Hospital of the Capital University of Medical Sciences, Beijing 100029, China
TANG Xiao-bin
Department of Vascular Surgery, Beijing Anzhen Hospital of the Capital University of Medical Sciences, Beijing 100029, China
ZHANG Xue-ning
Department of Vascular Surgery, Beijing Anzhen Hospital of the Capital University of Medical Sciences, Beijing 100029, China
WU Qing-hua
Department of Vascular Surgery, Beijing Anzhen Hospital of the Capital University of Medical Sciences, Beijing 100029, China