Sarpogrelate hydrochloride in the treatment of chronic arterial ischemia of the lower extremities
CHENG Jun, WANG Xue-hu, XIAO Le, SUN Jian-ming, WANG Kun, ZHENG Jiang-hua, ZHAO Yu, SHI De
Published 2012-11-25
Cite as Chin J Gen Surg, 2012,27(11): 890-892. DOI: 10.3760/cma.j.issn.1007-631x.2012.11.010
Abstract
Objective To evaluate the clinical efficacy of oral Sarpogrelate hydrochloride in the treatment of chronic arterial ischemia of the lower extremities.Methods In this study 892 patients,who suffered from arteriosclerosis (ASO) or thromboangiitis obliterans ( TAO ) or diabetic foot ( DF ),with symptoms of intermittent claudication, sensation of cold, pain, ulcer, and without a history of vasotransplantation or bypass grafting or interventional therapy, were treated by taking Sarpogrelate hydrochloride tablets 100 mg tid for consecutive 8 weeks.The improvement rate of concomitant symptoms and the total effective rate of ASO, TAO, DF were evaluated.Drug adverse reaction were recorded.Results The improvement rate of intermittent claudication,sensation of cold,pain and ulcer were 96.9%,97.1%,89.0% and 86.9% respectively.The total effective rate for ASO,TAO,DF was 83.5%.A total of 81 cases (9.1%) reported mild side effects,including 7 patients with mild rash after 2- 5 days' medication,21 patients with mild nausea and 53 patients with stomach discomfort after 1 - 2 days' medication.Symptoms were managed conservatively without discontinuing taking sarpogrelate hydrochloride.Conclusions Sarpogrelate hydrochloride oral is a safe and effective therapy for chronic arterial ischemia diseases of the lower extremities.
Key words:
Arterial occlusive diseases; Drug therapy; Sarpogrelate hydrochloride; Chronic arterial ischemia
Contributor Information
CHENG Jun
Department of Vascular Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
WANG Xue-hu
Department of Vascular Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
XIAO Le
Department of Vascular Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
SUN Jian-ming
Department of Vascular Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
WANG Kun
Department of Vascular Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
ZHENG Jiang-hua
Department of Vascular Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
ZHAO Yu
Department of Vascular Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
SHI De
Department of Vascular Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China