The effect of surgical resection on the prognosis of colorectal carcinoma with synchronous hepatic metastases
Zhai Shengyong, Sun Xiaojing, Zhong Xiaodong, Deng Guopeng, Qu Jianjun
Published 2018-11-25
Cite as Chin J Gen Surg, 2018,33(11): 915-919. DOI: 10.3760/cma.j.issn.1007-631X.2018.11.006
Abstract
ObjectiveTo investigate the effect of surgical treatment on survival in colorectal carcinoma patients with synchronous hepatic metastasis.
MethodsThe retrospective case-control study was done on 953 consecutive patients with synchronous colorectal hepatic metastasesl from January 2003 to December 2013.
ResultsMedian survival time (46.7 months)and 5-year survival rate(32%) for patients with resected hepatic metastases was significantly superior to that of with nonoperative treatment (17 months, 4%). Expanded criteria for hepatic metastases resection raised resection rates (31% vs. 13.6%, P<0.05). For patients with resectable hepatic metastases, the inhospital cost for simultaneous resection group was lower than that in the staged resection group (36 698 vs. 45 134 RMB, P<0.05). For patients of asymptomatic primary tumor with unresectable hepatic metastases, resection of the primary tumor was associated with an improved median survival (18.0 vs. 15.0 months, P<0.05).
ConclusionsExpanding indications of hepatic metastases resection can improve survival in patients with synchronous colorectal hepatic metastases. Simultaneous resection of primary tumor and hepatic metastases were indicated in patients with resectable synchronous colorectal hepatic metastases. Resection of primary tumor was recommended for asymptomatic patients with unresectable hepatic metastases.
Key words:
Colorectal neoplasms; Metastasectomy; Survival analysis
Contributor Information
Zhai Shengyong
Department of Oncology Surgery, Weifang People′s Hospital, Weifang 261041, China
Sun Xiaojing
Zhong Xiaodong
Deng Guopeng
Qu Jianjun