Original Article
Preoperative GGT, ALT/AST relates to clinicopathological features and prognosis after radical surgery for hepatocellular carcinoma
Jie Zhao, Haibo Yu, Yunhai Zhu, Feng Cai, Xingchang He
Published 2019-04-25
Cite as Chin J Gen Surg, 2019, 34(4): 328-331. DOI: 10.3760/cma.j.issn.1007-631X.2019.04.011
Abstract
ObjectiveTo investigate the relationship between preoperative GGT(γ-glutamyl transferase), ALT/AST with clinicopathological features and prognosis after radical surgery of hepatocellular carcinoma(HCC).
MethodsThe clinical data of 187 HCC patients undergoing radical resection in our hospital were retrospectively analyzed. Survival analysis was performed using the Kaplan-Meier analysis method to estimate the survival rate, and Log-rank analysis was used to compare survival rates between groups. Cox proportional hazards model was used for univariate and multivariate survival analysis.
ResultsThe Kaplan-Meier curves showed that HCC patients with normal GGT leval and higher ALT/AST ratio had a longer survival time than those with higher GGT leval and those with lower ALT/AST ratio (all P<0.05). The multivariate analyses showed that GGT leval and TNM staging were independent factors in predicting overall survival time in HCC patients.
ConclusionsGGT is a predictive index of overall survival of HCC patients.
Key words:
Carcinoma, hepatocellular; gamma-Glutamyltransferase; Tramsaminases; Prognosis
Contributor Information
Jie Zhao
Department of Gastrointestinal Hepatobiliary Surgery, Shangqiu First People′s Hospital , Shangqiu 476000, China
Haibo Yu
Department of Hepatobiliary Surgery, He′nan People′s Hospital, Zhengzhou 450003, China
Yunhai Zhu
Department of Gastrointestinal Hepatobiliary Surgery, Shangqiu First People′s Hospital , Shangqiu 476000, China
Feng Cai
Department of Gastrointestinal Hepatobiliary Surgery, Shangqiu First People′s Hospital , Shangqiu 476000, China
Xingchang He
Department of Gastrointestinal Hepatobiliary Surgery, Shangqiu First People′s Hospital , Shangqiu 476000, China
