Clinical biological characteristics of metastatic carcinoma of the thyroid: a report of 30 cases
Yu Wu, Xiangrui Meng, Linfei Hu, Xiukun Hou, Jingtai Zhi, Jun Zhang, Huijuan Wang, Hui Liu, Xiangqian Zheng, Ming Gao
Abstract
ObjectivesTo study the clinical characteristics, diagnosis, treatment and prognosis of cancer metastases to the thyroid gland.
MethodsAt Tianjin Medical University Cancer Hospital, from 1980 to 2016 30 patients were identified with a metastatic malignant tumor of the thyroid gland.
ResultsPrimary tumor sites were in the esophagus (26.7%), lung (16.7%), and kidney (13.3%). The median age at discovery of thyroid metastasis was 56 years old. The time lapse ranged from 0 to 108 months. There were 18 patients with metachronous metastasis with median survival of 36 months, 12 patients were with synchronous metastasis, and the median survival was 8 months(P<0.01). 20 patients were treated with thyroid surgery, and of which 15 patients were given post-op radiotherapy and chemotherapy. Patients who underwent thyroid resection had a median survival of 15 months, while that was 8 months in those without thyoid surgery (P<0.01).
ConclusionsMetastases to the thyroid gland is a rare clinical phenomenon, the prognosis of patients is mainly related to the biological behavior of primary tumors, but surgical resection and combined treatment can increase the survival rate.
Key words:
Neoplasms metastasis; Thyroid; Prognosis
Contributor Information
Yu Wu
Department of Head and Neck Surgery, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital Fuzhou 350014, China
Xiangrui Meng
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Linfei Hu
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Xiukun Hou
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Jingtai Zhi
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Jun Zhang
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Huijuan Wang
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Hui Liu
Department of Head and Neck Surgery, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital Fuzhou 350014, China
Xiangqian Zheng
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Ming Gao
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
