Preoperative platelet-to-lymphocyte count ratio predicts peritoneal metastasis in patients with advanced gastric cancer
Pang Wenyang, Chen Wenjing, Zhu Guanbao, Hu Changyuan, Cai Yiqi
Published 2019-10-25
Cite as Chin J Gen Surg, 2019,34(10): 828-832. DOI: 10.3760/cma.j.issn.1007-631X.2019.10.002
Abstract
ObjectiveTo assess the predictive value of the platelet-to-lymphocyte ratio(PLR), neutrophil-to-lymphocyte ratio(NLR)and tumor-related factors on the peritoneal metastasis in advanced gastric cancer patients.
MethodsA total of 701 pathologically confirmed gastric cancer patients who underwent surgery at the First Affiliated Hospital of Wenzhou Medical University between Jan 2009 and Jan 2012 were enrolled.
ResultsUnivariate analysis indicated that tumor location, tumor size, serosal invasion, depth of invasion, pathological type, lymph node metastasis and PLR were related to peritoneal metastasis(all P<0.05). According to the area under the ROC curve, the optimal cutoff value of PLR for predicting peritoneal metastasis was 132.43 (sensitivity 71.8%, specificity 50.6%). There were significant differences in tumor size, TNM stage, lymph node metastasis and serosal infiltration between high PLR group and low PLR group. Multivariate Logistic analyses revealed that PLR (HR=2.205, P=0.003), lymph node metastasis(HR=3.113, P=0.010)and tumor size(HR=1.150, P=0.014) were independent risk factors for peritoneal metesfasis.
ConclusionsPreoperative PLR is valuable in predicting peritoneal metastasis of advanced gastric cancer and it is an independent risk factor for peritoneal metastasis of gastric cancer.
Key words:
Stomach neoplasms; Platelet; Lymphocyte; Neoplasm metastasis
Contributor Information
Pang Wenyang
Department of Surgical Oncology, Taizhou Municipal Hospital, Taizhou 318000, China
Chen Wenjing
Department of General Surgery, the First Affiliated Hospital , Wenzhou Medical University, Wenzhou 325035, China
Zhu Guanbao
Department of General Surgery, the First Affiliated Hospital , Wenzhou Medical University, Wenzhou 325035, China
Hu Changyuan
Department of General Surgery, the First Affiliated Hospital , Wenzhou Medical University, Wenzhou 325035, China
Cai Yiqi
Department of General Surgery, the First Affiliated Hospital , Wenzhou Medical University, Wenzhou 325035, China
