To study the therapeutic effect of pinaverium bromid and oryz-aspergillus enzyme and pancreatin tablet on patients with bile duct Ⅲ of sphincter of Oddi dysfunction (SOD) after cholecystectomy.

72 patients who had a diagnosis consistent with bile duct Ⅲ of SOD seen from February 2010 to February 2013 in our hospital were randomly divided into the control group and the treatment group. Patients in the control group were given pinaverium bromid for 3 months while patients in the treatment group were, in addition to pinaverium bromid, given oryz-aspergillus enzyme and pancreatin tablet. Relief of abdominal pain, abdominal distention and recurrence of the above symptoms after drug withdrawal were studied.

The scores on abdominal pain in the treatment group before and after treatment were 7.5±1.1 and 3.0±1.6(P<0.05) while the scores in the control group were 7.4±1.1 and 5.0±1.4 (P<0.05), respectively. Alleviation of abdominal pain in the treatment group was superior to the control group (P<0.05). The scores on abdominal distention in the treatment group before and after treatment were 5.4±0.6 and 1.6±0.5 (P<0.05) while the scores in the control group were 5.2±0.5 and 4.7±0.8 (P>0.05), respectively. Alleviation of abdominal distention in the treatment group was superior to the control group (P<0.05). The scores of abdominal pain and distention in half year after 3 months' therapy in the treatment group were 3.1±1.7 and 1.7±1.1, respectively, which obviously were lower than the control group (5.4±1.4 and 5.0±0.6, P<0.05).

Pinaverium bromid and oryz-aspergillus enzyme and pancreatin tablet could effectively alleviate abdominal pain and distention in patients with bile duct Ⅲ of SOD after cholecystectomy and the recurrence rates of symptoms were significantly lower.

Cholecystectomy; Sphincter of oddi dysfunction, bile duct Ⅲ; Clinical effect