Original Article
Prognosis and clinical outcome analysis of 29 cases with T1a unsuspected gallbladder carcinoma
Wenlong Liu, Yuanhu Tian, Bin Liang, Yang Liu, Tao Yang, Xianlei Xin, Huaiyin Shi, Bo Liu
Published 2016-03-28
Cite as Chin J Hepatobiliary Surg, 2016, 22(3): 176-179. DOI: 10.3760/cma.j.issn.1007-8118.2016.03.009
Abstract
ObjectiveTo summarize the clinicopathological features of T1a unsuspected gallbladder carcinoma (UGC), investigate the therapeutic strategy and identify the potential prognostic factors.
MethodsA retrospective study was carried out on 29 cases diagnosed as T1a UGC during or after Laparoscopic cholecystectomy (LC) from January 2003 to July 2014. The demographic and clinical data were collected and analyzed.
ResultsOf the 29 T1a UGC diagnosed during (n=11) or after (n=18) LC, 26 cases underwent simple LC. 1 case converted to simple open cholecystectomy (OC) because of severe cholecystitis and 1 case underwent additional radiofrequency ablation of gallbladder bed and was diagnosed during LC by frozen section. 1 case underwent radical resection 24 days later. No lymph node metastasis, vascular invasion and perineural invasion were founded in the 29 cases and resection margin was tumor negative. During the study period, 2 patients died. One case died of disseminated metastasis in the abdominal cavity and the other of primary hepatic carcinoma. The 1-, 3-, 5-year accumulative survival rate of the 27 cases after simple cholecystectomy was 100%, 96.2%, 96.2%, and the other two cases with radiofrequency ablation of gallbladder bed and radical resection of UGC both had long-term survival.
ConclusionSimple cholecystectomy is appropriate for T1a UGC patients, but the complete resection of the gallbladder is essential for improving the patients' outcome.
Key words:
Unsuspected gallbladder carcinoma; Early-stage gallbladder carcinoma; Therapy; Laparoscopic cholecystectomy; Prognosis
Contributor Information
Wenlong Liu
Department of Hepatobiliary Surgery, PLA General Hospital, Beijing 100853, China
Yuanhu Tian
Bin Liang
Yang Liu
Tao Yang
Xianlei Xin
Huaiyin Shi
Bo Liu