Original Article
Postoperative prophylactic transcatheter arterial chemoembolization on early recurrence in patients with hepatocellular carcinoma with microvascular invasion
Qi Yapeng, Yang Haojie, Yang Fuquan, Feng Xuzhuo, Chen Yong, Yuan Weiping, Xiang Bangde, Li Lequn
Published 2016-09-28
Cite as Chin J Hepatobiliary Surg, 2016,22(09): 607-610. DOI: 10.3760/cma.j.issn.1007-8118.2016.09.008
Abstract
ObjectiveTo study the effects of postoperative prophylactic transcatheter arterial chemoembolization (TACE) on early recurrence (≤1 year) in patients with hepatocellular carcinoma (HCC) with microvascular invasion.
MethodsWe collected the clinical data of HCC patients treated with radical hepatectomy from Cancer Hospital of Guangxi Medical University between January 2012 and December 2013, and 127 eligible cases with microvascular invasion were reviewed. According to the treatment with or without TACE, the patients were divided into hepatectomy alone group (groupⅠ, n=86) and combined with TACE group (group Ⅱ, n=41). The PSM (Propensity Score Matching) of SPSS software was used to reduce confounding bias between the two groups, and the disease free survival rates were compared between the matched data.
ResultsThirty-nine pairs were matched with PSM for balancing covariates in the two groups. The relapse-free survival rates of 4, 8 and 12-month were all significantly higher in the group Ⅱ (89.7%, 76.1%, 62.8%) than that in group Ⅰ (68.3%, 57.8%, 41.4%). There were significantly statistical differences (χ2=4.247, P<0.05). Cox regression analysis revealed serum AST level was an independent prognostic factor associated with poor early recurrence.
ConclusionProphylactic TACE after radical resection might have benefits in delaying early-onset recurrence for HCC patients with microvascular invasion.
Key words:
Hepatocellular carcinoma; Prophylactic transcatheter arterial chemoembolization; Early recurrence; Microvascular invasion
Contributor Information
Qi Yapeng
Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China
Yang Haojie
Yang Fuquan
Feng Xuzhuo
Chen Yong
Yuan Weiping
Xiang Bangde
Li Lequn