Review
Research progress of the relationship between chronic inflammation and pancreatic ductal adenocarcinoma
Li Chunyan, Hu Yong, Cui Yunfeng
Published 2019-08-28
Cite as Chin J Hepatobiliary Surg, 2019, 25(8): 636-640. DOI: 10.3760/cma.j.issn.1007-8118.2019.08.020
Abstract
Studies have demonstrated a strong correlation between chronic inflammation and tumor initiation and progression. Chronic inflammation is mainly involved in tumor progression through intrinsic and extrinsic pathways, and transcription factors such as NF-κB and STAT3 play important roles. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Chronic inflammation can promote the development of PDAC in cooperation with mutation of protooncogene. Inflammation signaling pathway plays an important role in malignant transformation in the PDAC, in which NF-κB and STAT3 are two major transcription factors. Targeting the key regulator points based on the crosstalk between inflammation signaling and PDAC may potentially represent a novel for PDAC prevention and treatment. This article briefly reviews the role of chronic inflammation in the development of PDAC, the PDAC-related inflammatory signal network caused by chronic inflammation, and crosstalk between NF-кB and JAK/STAT3 signaling pathways.
Key words:
Pancreatitis, chronic; Pancreatic intraductal neoplasms; NF-kappa B; STAT3 transcription factor; Pancreatic neoplasms
Contributor Information
Li Chunyan
Graduate School of Tianjin Medical University, Tianjin 300070, China
Hu Yong
Graduate School of Tianjin Medical University, Tianjin 300070, China
Cui Yunfeng
Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin 300100, China
