Original Article
Network Meta-analysis on the efficacy and safety of surgical resection and thermal ablations for hepatocellular carcinoma in China
Kun Xiong, Liping Zhu, Yong Lu, Bing Shen, Di Xue
Published 2019-11-28
Cite as Chin J Hepatobiliary Surg, 2019, 25(11): 823-827. DOI: 10.3760/cma.j.issn.1007-8118.2019.11.007
Abstract
ObjectiveTo compare the efficacy and safety of surgical resection and thermal ablations in patients with hepatocellular carcinoma in China using a network Meta-analysis.
MethodsReferences related to eligible randomized controlled studies (RCTs) were searched from China Biology Medicine, China National Knowledge Infrastructure(CNKI), PubMed, Embase and Cochrane Library from 1st January 2010 to 1st December 2017, and were selected according to the criteria. The 1-year, 3-year, and 5-year survival rates and incidence of serious complications were compared among surgical resection (SR), radiofrequency ablation (RFA), and microwave ablation(MWA) by network Meta-analysis based frequency and Bayesian methods.
ResultsA total of 24 RCTs were included in this study. The results of surface under the cumulative ranking probabilities (SUCRA) showed that when all RCTs were included, the frequency model supported MWA had the highest 5-year overall survival rate (66.1%), while the Bayesian model supported SR had the highest 5-year overall survival rate (64.7%). When the tumor diameter of hepatocellular carcinoma was less than 5 cm and the liver function was Child-Pugh A/B, the frequency and Bayesian model both supported SR had the highest 5-year overall survival rate (89.1% and 88.3%, respectively). When all RCTs or RCTs were included with the tumor diameter less than 5 cm and liver function was Child-Pugh A/B, both the frequency and the Bayesian model supported RFA had the best safety (serious complications rate) (16.4%, 18.7%, 12.6 and 12.8%, respectively).
ConclusionSR should be the first choice for early and small hepatocellular carcinoma, while RFA and MWA have their own indications.
Key words:
Carcinoma, hepatocellular; Radiofrequency ablation; Microwave ablation; Surgical resection; Meta-analysis
Contributor Information
Kun Xiong
School of Public Health, Fudan University
Key Laboratory of Health Technology Assessment, National Health Commission, Shanghai 200031, China
Liping Zhu
School of Public Health, Fudan University
Key Laboratory of Health Technology Assessment, National Health Commission, Shanghai 200031, China
Yong Lu
Department of Radiology, Ruijin Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
Bing Shen
Transplantation Urology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
Di Xue
School of Public Health, Fudan University
Key Laboratory of Health Technology Assessment, National Health Commission, Shanghai 200031, China
