Cardiovascular and Cerebrovascular Diseases
C-reactive protein and other cardiovascular biomarkers are prediction of long-term outcomes in patients undergoing percutaneous coronary intervention
Wu Jiong, Guo Wei, Liu Xiaowen, Wang Chong, Xu Wen, Zhang Chunyan, Song Binbin, Wang Beili, Pan Baishen
Published 2014-03-11
Cite as Chin J Lab Med, 2014,37(03): 213-218. DOI: 10.3760/cma.j.issn.1009-9158.2014.03.013
Abstract
ObjectiveThe association of high-sensivity C-reactive protein (hs-CRP) on patients undergoing percutaneous coronary intervention （PCI） and the long-term prognostic value were evaluated.
Methods A prospective cohort study was prospectively conducted in 287 consecutive patients who were hospitalized in the Department of Cardiology of Shanghai Zhongshan Hospital undergoing primary PCI between Dec.2007 and Dec.2008. Levels of hs-CRP and other cardiovascular risk factors were determined before PCI. The patients were followed up for a mean of 54 months. Their cardiovascular end points were recorded.
ResultsThe mean value of serum hs-CRP in patients with cardiovascular disease （CVD） readmission and death was significantly higher than those without CVD readmission and death (2.21 mg/L versus 1.10 mg/L, Z=-3.152；6.60 mg/L versus 1.22 mg/L, Z=-3.192；P both <0.05). The cardiac troponin T, WBC ,multivessel disease, stent placement and the low HDL-C are the factors relating to serum hs-CRP levels. The coefficients of correlation have statistical significance (t=8.575, 4.763 and -2.770;P<0.05). The odd ratios for CVD readmissiom and CVD death were 1.714（95%CI, 1.164-2.523）and 5.023（95%CI, 2.003-12.600）. Kaplan-Meier survival analysis demonstrated a significantly reduced 5-year readmission rate in patients with 3.65＜hs-CRP≤82.51 mg/L ［43.75%（30/71）groups versus the lower hs-CRP level groups(20.83%,15/72); χ2=10.375,P<0.001by Log-rank］. The same as the death rate ［9.86%（7/71）were evaluated in the lower hs-CRP level groups(1.38%,1/72);χ2=11.362, P<0.05 by Log-rank］. The readmission rate and mortality in the patients with hs-CRP>3.0 mg/L are 43.75%（35/80）and 8.75%（7/80）,respectively. The survival time was all less than 20 months.
ConclusionsThe results demonstrated that hs-CRP is an independent risk factor in cardiovascular disease. High hs-CRP is strongly associated with 5-year occurance of readmission and death for cardiovascular events. Hs-CRP can be a strong indicator of risk stratification and prognostic evaluation on cardiovascular high-risk populations. （Chin J Lab Med,2014,37:213-218）
Key words:
Cardiovascular diseases; C-reactive protein; Biological markers; Prognosis
Contributor Information
Wu Jiong
Department of Laboratory Medicine，Zhongshan Hospital of Fudan University, Shanghai 200032, China
Guo Wei
Liu Xiaowen
Wang Chong
Xu Wen
Zhang Chunyan
Song Binbin
Wang Beili
Pan Baishen
