The role of autophagy in neuronal ischemic injury and its relationship with apoptosis and necrosis
LU Kongmiao, PAN Shuming
Published 2016-06-10
Cite as Chin J Emerg Med, 2016,25(6): 843-846. DOI: 10.3760/cma.j.issn.1671-0282.2016.06.034
Abstract
Ischemic stroke is the major cause of disability and death. Although autophagy is widely involved in the process of acute brain ischemia, the exact role of autophagy is still unclear. As autophagy is a double-edged sword, its protect or damage impact mainly depends on the degree of phagocytosis.In general, moderate phagocytosis can effectively remove excess metabolites, aging organelles, etc; whereas the excessive autophagy is vulnerable to autophagy-like cell death by virture of the normal intracellular organelles and materials degraded by lysosome. In conclusion, this review focuses on the following two points: 1. What's the role of autophagy in the ischemic brain injury——protective or damage 2. How does autophagy interact with apoptosis and necrosis
Key words:
Autophagy; Neuron; Hypoxia-Ischemia, Brain; Apoptosis; Necrosis
Contributor Information
LU Kongmiao
Department of Emergency, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China; General ICU, Second Affiliated Hospital, Zhejiang University School of Medicine, hanghzou 310052, China
PAN Shuming
Department of Emergency, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
