Clinical Medicine
The clinical value of combined detection of serum angiopoietin 2 and Clara cell protein 16 in the early diagnosis of acute respiratory distress syndrome
Jianbin Ye, Jinle Lin, Chao Zhong, Jianqing Ye, Min Shi, Jian Wei, Xuan Fu, Shiyong Zeng, Wuyuan Tao, Qinglin Dou, Wenwu Zhang
Published 2019-09-10
Cite as Chin J Emerg Med, 2019, 28(9): 1112-1117. DOI: 10.3760/cma.j.issn.1671-0282.2019.09.010
Abstract
ObjectiveTo investigate the clinical value of combined detection of serum angiopoietin 2 (Ang-2) and Clara cell protein 16 (CC16) in the early diagnosis of acute respiratory distress syndrome (ARDS).
MethodsTwo hundred critical patients, treated at the Department of Critical Care Medicine, Bao'an District People's Hospital, Shenzhen during March 2015 and September 2016,were included in the study. According to the Berlin standard, patients were divided into two groups (n=100 each group): the ARDS group and non-ARDS group.The serum levels of Ang-2 and CC16 were measured by enzyme-linked immunosorbent assay (ELISA) on the first and second day of admission for each patient, in addition to completing APACHEⅡ score, medical history, vital signs collection and other biochemical indicators detection. Finally, paired-samples t test was used to analyze the data. The multiple ROC curve was used to calculate the area under the curve of the reference index of the serum levels of Ang-2 and CC16 on the first and second day.
ResultsOn the first and second day, the serum levels of Ang-2 and CC16 were significantly higher in ARDS patients than those in non-ARDS patients, and there was a correlation between the serum levels of Ang-2 and CC16 in ARDS patients. The ROC curve showed that the combined detection of Ang-2 and CC16 on the first day achieved a highest sensitivity of 75.9% and detection of CC16 on the first day achieved a highest specificity of 70.2%.
ConclusionSingle-detection of serum levels of Ang-2 and CC16 could be used for early diagnosis of ARDS, and the combined detection of both has a higher sensitivity than single detection.
Key words:
Angiopoietin 2; Clara cell protein 16; Acute respiratory distress syndrome; Combined detection; Early diagnosis
Contributor Information
Jianbin Ye
Intensive Care Unit, Puning People’s Hospital, Puning 515300, China
Jinle Lin
Emergency Department, Bao'an People’s Hospital, Shenzhen 518101, China
Chao Zhong
Gastroenterology Department, Puning People’s Hospital, Puning 515300, China
Jianqing Ye
Emergency Department, Puning Xiajiashan’s Health Center, Puning 515300, China
Min Shi
Emergency Department, Bao'an People’s Hospital, Shenzhen 518101, China
Jian Wei
Emergency Department, Bao'an People’s Hospital, Shenzhen 518101, China
Xuan Fu
Emergency Department, Bao'an People’s Hospital, Shenzhen 518101, China
Shiyong Zeng
Emergency Department, Bao'an People’s Hospital, Shenzhen 518101, China
Wuyuan Tao
Emergency Department, Bao'an People’s Hospital, Shenzhen 518101, China
Qinglin Dou
Emergency Department, Bao'an People’s Hospital, Shenzhen 518101, China
Wenwu Zhang
Emergency Department, Bao'an People’s Hospital, Shenzhen 518101, China
