To investigate the value and effects of lipoinjection into the subperiosteal and overlying multiple planes for correction of facial depression.

The lateral and posterolateral areas of the thigh and infragluteal areas were selected as donor sites of autologous fat. The fat was rinsed and purified after liposuction. The collected fat was injected into the subperiosteal and overlying multiple planes to correct facial depression.

96 patients received lipoinjection of volume between 0.5 to 22 ml for each unilateral depression each time. Secondary injection was performed after 4 to 8 months after operation if necessary. The depression was corrected, the skin texture was improved, the wrinkles were also improved after fat transplantation. The follow-up period was between 6 and 24 months. 3 patients had sclerosis after lipoinjection. The sclerosis disappeared after 6 months through local massage, hot compress, and traditional medicine treatment in two of them. The sclerosis was resolved by excision in the rest one. There were no complications of hematoma, infection, liquefaction, and calcification.

Lipoinjection into the subperiosteal and overlying multiple planes can correct facial depression with fat. Fat survival rate is high. The method is suitable for correction of facial depression in aesthetic plastic surgery.

Facial depression; Fat transplantation; Soft tissue