Original Article
Efficacy and safety of short-term intensive statin therapy in patients with acute coronary syndrome
Lina Sun, Ningfu Wang, Lan Kang, Wei Gao, Hong Li, Lei Lai, Hao Pan, Xianhua Ye, Liang Zhou, Guoxin Tong, Jianmin Yang, Peng Xu, Zhanlin Zhou
Published 2014-05-04
Cite as Chin J Gen Pract, 2014, 13(5): 365-369. DOI: 10.3760/cma.j.issn.1671-7368.2014.05.012
Abstract
ObjectiveTo evaluate the clinical efficacy and safety of short-term intensive statin therapy in patients with acute coronary syndrome (ACS).
MethodsA total of 218 ACS patients admitted in Hangzhou First People's Hospital from March 2013 to July 2013 were enrolled into this study. The patients were randomly assigned to receive atorvastatin 80 mg/d during hospitalization, and 40 mg/night after discharge for one month (intensive group, n=107); or receive atorvastin 20 mg during hospitalization and 20 mg/night after discharge for one month (control group, n=111). The biochemical indexes were measured on the admission and after one-month treatment.
ResultsAfter one-month treatment, the total cholesterol, triglycerides and LDL cholesterol of intensive group were significantly lower, and the high density lipoprotein cholesterol was higher than baseline values (0.75±0.14)mmol/L vs. (1.52±0.88)mmol/L, P<0.05; (2.21±0.78)mmol/L vs.(4.55±1.12)mmol/L, P<0.05; (1.76±0.31)mmol/L vs.(2.23±0.77) mmol/L, P<0.05; (1.15±0.34) vs.(1.52±0.41)mmol/L, P<0.05. The liver enzymes creatine kinase in intensive group was not significantly changed, but the creatinine levels decreased (82.53±23.85)μmol/L vs.(57.81±15.27) μmol/L, P<0.05, and the blood homocysteine and ultra-sensitivity C-reactive protein levels also decreased compared with the baseline (10.52±4.66)mmol/L vs.(30.70±18.82) mmol/L, P<0.05; (8.06±2.68)mg/L vs.(19.75±11.91)mg/L, P<0.05.
ConclusionsShort-term intensive statin therapy can effectively reduce blood lipid, cholesterol and homocysteine levels and raise HDL cholesterol levels; also with its anti-inflammatory and renal protective effect the therapy can provide more clinical benefit for patients with ACS.
Key words:
Coronary Disease; Antilipemic agents; Treatment outcome
Contributor Information
Lina Sun
Hangzhou First People's Hospital Affiliated to Nanjing Medical University, Hangzhou 310006, China
Ningfu Wang
Lan Kang
Wei Gao
Hong Li
Lei Lai
Hao Pan
Xianhua Ye
Liang Zhou
Guoxin Tong
Jianmin Yang
Peng Xu
Zhanlin Zhou