To investigate the effect of hypertension and hyperuricemia (HUA) on renal function.

Total 1 209 subjects undergoing health check up from December 2000 to December 2002 and 45 patients with renal disorders were enrolled in the study. The blood pressure, height, weight, renal function and liver function were measured; and the glomerular filtration rate (GFR) was calculated. The GFR in patients with hypertension, HUA and hypertension with HUA was compared.

The incidence of hypertension in HUA group and non-HUA was 23.9%(58/243) and 13.9%(134/966), respectively (χ²=14.52, P=0.000). GFR in HUA with hypertension, HUA and hypertension groups were (69.1±30.5), (82.8±25.3) and (90.1±21.7)ml·min^-1·(1.73 m²)^-1, respectively (P<0.01). Logistic regression analysis showed that the risk factors for GFR were UA, systolic pressure and age. After 5 years of follow up, GFR in hypertension group was significantly decreased from (90.7±18.1) to (85.6±17.6)ml·min^-1·(1.73 m²)^-1m, in HUA group from (86.3±10.9) to (62.1±8.2) and in HUA with hypertension group from (77.9±18.9) to (49.3±9.8) ml·min^-1·(1.73 m²)^-1, UA and age were the long-term factors that affect GFR (P<0.05).

Both hyperuricemia and hypertension can impair the kidney function, if hypertension is complicated with hyperurecemia the effect is more marked.

Hypertension; Hyperuricemia; Glomerular filtration rate