Original Article
Complications and related risk factors in Uygur patients with type 2 diabetes mellitus
Guoli Du, Yinxia Su, Jun Zhu, Sheng Jiang, Jing Xu, Yimingjiang Ayiguli·, Fugang Chen, Hua Yao
Published 2019-04-04
Cite as Chin J Gen Pract, 2019, 18(4): 358-364. DOI: 10.3760/cma.j.issn.1671-7368.2019.04.013
Abstract
ObjectiveTo investigate the prevalence of complication and related risk factors in Uygur patients with type 2 diabetes mellitus (T2DM).
MethodsTotal 1 507 Uygur patients aged above 20 with T2DM were recruited in the First Affiliated Hospital of Xinjiang Medical University from January 2010 to October 2015. Clinical characteristics, biochemical parameters and related complications were analyzed in different age groups of patients. Multivariate logistic regression was performed to determine associated factors for diabetic complications.
ResultsAmong 1 507 cases, there were 61.3% male patients (n=924), 37.4% (n=564) with diabetes duration ≥5 years, 12.5% (n=189) with HbA1c>10%, 31.5% (n=475) with hypertension, 28.8% (n=434) with smoking history and 37.4% (n=564) patients without antidiabetic drug treatment. The average body mass index (BMI) of patients was (27.4±5.2) kg/m2 with a obesity rate of 43.0% (648/1 507), and 65.0% (980/1 507) had physical exercise<150 min/week. The prevalence of diabetic complication was 70.6%(1 064/1 507), in which 28.7%, 19.2% and 22.7% cases had 1, 2 and 3 or more complications, respectively. The proportion of patients with coronary heart disease, stroke/transient ischemic attack and large artery atherosclerosis was 32.4%, 10.4% and 35.8%, respectively. The proportion of patients with diabetic retinopathy, nephropathy and neuropathy were 23.4%, 6.5% and 35.8%, respectively. Patients aged ≥60 years had highest prevalence of large artery atherosclerosis (38.2%,163/427) and diabetic retinopathy (27.2%, 116/427); patients in age group 50-59 years had highest prevalence of diabetic neuropathy (40.3%, 207/514). Multivariate logistic regression analysis showed that HbA1c>10% (OR=2.74, 95%CI: 1.40-5.34), obesity (OR=1.54, 95%CI: 1.07-2.21), systolic pressure≥140 mmHg (1 mmHg=0.133 kPa) (OR=1.42, 95%CI: 1.01-1.99), diastolic pressure≥90 mmHg (OR=0.37, 95%CI: 0.21-0.67), smoking (OR=1.53, 95%CI: 1.09-2.15) and physical activity<150 min/week (OR=1.42, 95%CI: 1.07-1.89) were the risk factors of diabetic complications.
ConclusionUygur patients with type 2 diabetes in Xinjiang show a relatively high prevalence of complications.Poor glycemic control,obesity,hypertension,smoking and physical inactivity may contribute to development of complications, while well-controlled blood glucose and hypertension and quitting smoking and increasing physical activity may reduce diabetic complications.
Key words:
Diabetes mellitus, type2; Diabetes complications; Age factors; Disease duration; Blood glucose
Contributor Information
Guoli Du
Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Yinxia Su
The Center of Health Management, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Jun Zhu
Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Sheng Jiang
Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Jing Xu
Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Yimingjiang Ayiguli·
Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Fugang Chen
Department of Gynecology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Hua Yao
The Center of Health Management, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
