Original Article
Effect of enteral nutrition support on hematological complications in children with malignant solid tumor during chemotherapy
Li Fan, Zhang Weiling, Ren Weishan, Zhu Xia, Hu Huimin, Zhi Tian, Zhang Yi, Huang Dongsheng
Published 2022-02-04
Cite as Chin J Gen Pract, 2022, 21(2): 154-160. DOI: 10.3760/cma.j.cn114798-20211120-00865
Abstract
ObjectiveTo investigate the effect of enteral nutrition on hematological complications in children with malignant solid tumors during chemotherapy.
MethodsA total of 103 children with malignant solid tumor admitted to our hospital from March 2020 to December 2020 were enrolled in the study. The children were randomly divided into enteral nutrition group (n=51) and control group (n=52). Children in enteral nutrition group were given enteral nutrition support on the basis of routine diet, while children in control group were only given routine diet. The levels of leukocytes, neutrophils, hemoglobin and platelets in peripheral blood of children during chemotherapy were analyzed. The incidence of infection and the transfusion of red blood cells and platelets after chemotherapy were documented and compared between two groups.
ResultsThe levels of white blood cells, neutrophils, hemoglobin and platelets before chemotherapy were significantly higher than those after chemotherapy both in enteral nutrition group (Z=-5.91, -5.59, -5.54, -5.66, all P<0.05) and in control group (Z=-6.14, -5.84, -5.75, -4.75, all P<0.05). The overall hemoglobin levels in enteral nutrition group before and after chemotherapy was significantly higher than those in control group (t=5.68, 5.62, P<0.05), and there were no significant differences in the levels of white blood cells, neutrophils and platelets between the two groups before chemotherapy (Z=-0.71, -0.12, -1.29, all P>0.05) and after chemotherapy (Z=-0.39, -0.86, -0.94, all P>0.05). Compared with the control group, the degree of anemia during chemotherapy was significantly improved in enteral nutrition group (χ²=10.45,6.12, all P<0.05), but there was no significant difference in the reduction degree of white blood cells, neutrophils and platelets between the two groups (before chemotherapy: χ²=1.17, 0.10, 0.49; after chemotherapy: χ²=0.18, 1.10, 0.97, all P>0.05). The number of children receiving red blood cell transfusion in enteral nutrition group was significantly lower than that in control group (χ²=14.06, P<0.05), and there was no significant difference in the number of children with infection and platelet transfusion between the two groups (χ²=1.20, 0.29, all P>0.05).There was no significant difference in the duration of neutrophil deficiency between enteral nutrition group and control group (t=-1.75, P>0.05).
ConclusionEnteral nutrition support can significantly improve the hemoglobin level in children during chemotherapy, effectively alleviate the severity of anemia, and reduce the incidence of red blood cell transfusion after chemotherapy, which has high clinical application value.
Key words:
Nutritional support; Children; Neoplasms; Anemia; Chemotherapy
Contributor Information
Li Fan
Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Zhang Weiling
Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Ren Weishan
Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Zhu Xia
Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Hu Huimin
Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Zhi Tian
Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Zhang Yi
Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Huang Dongsheng
Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
