Relationship of CD62E+microparticles level with degree of severity, prognosis and vascular risk factors in patients with acute cerebral infarction
Zhang Liang, Liu Yajie, He Xiongjun, Li Kaifeng
Published 2014-04-15
Cite as Chin J Neuromed, 2014,13(04): 388-392. DOI: 10.3760/cma.j.issn.1671-8925.2014.04.015
Abstract
Objective To explore the level of CD62E+ endothelial microparticles in acute cerebral infarction patients and its relationship with vascular risk factors,degree of severity and prognosis.Methods Seventy patients with acute cerebral infarction and 70 non-cerebral infarction patients (controls),admitted to our hospital from January 2013 to September 2013,were selected in our study; U.S.national institutes of health stroke scale (NIHSS) was performed to evaluate the degree of severity; Barthel index (BI) was used to evaluate the prognosis; the levels of blood lipids,blood glucose,uric acid,fibrinogen (FIB),homocysteine (Hcy),C-reactive protein (CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) were routinely measured; CD62E+ levels were detected by flow cytometry,and the relationships of CD62E+ level with vascular risk factors,degree of disease and prognosis were analyzed.Results The blood CD62E+ level of patients with acute cerebral infarction ([1.55 ±0.67]microparticle/μL) was significantly higher than that in the control group ([1.01 ±0.66] microparticle/μL,P<0.05); CD62E+ level in patients with NIHSS scores>5 ([2.03±0.61] microparticle/μL) was significantly higher than that in patients with NIHSS scores ≤ 5 ([1.25±0.37] microparticle/μL,P<0.05).Spearman correlation analysis showed that CD62E+ level was significantly correlated with the stroke severity (NHISS scores,r=0.537,P=0.000) and lipoprotein-associated phospholipase A2 (Lp-PLA2) level (r=0.327,P=0.006),and negatively correlated with prognosis indicator (r=-0.634,P=0.000); other factors showed no significant correlation.Conclusion CD62E+ microparticle can reflect the severity and prognosis of acute brain infarction,and it may be an important biological marker for clinical application.Besides,the correlation between Lp-PLA2 and CD62E+ means that the level ofCD62E+ micro particles is associated with the stability of athemsclerotic plaques.
Key words:
Acute cerebral infarction; Endothelial microparticles; CD62E+; Degree of severity; Prognosis; Risk factor
Contributor Information
Zhang Liang
Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Liu Yajie
Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
He Xiongjun
Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Li Kaifeng
Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China