Clinical Research
Clinicopathologic features of 2276 cases of pituitary adenomas of different types
Zhao Zhao, Jin Shumei, Zhang Xuebin, Tang Fan, Yan Xuejiang, Xue Kai, Yan Xiaoling, Yao Xin
Published 2015-10-15
Cite as Chin J Neuromed, 2015,14(10): 1031-1037. DOI: 10.3760/cma.j.issn.1671-8925.2015.10.012
Abstract
ObjectiveTo analyze the clinical and pathological features of pituitary adenomas of different types.
MethodsThe clinical data of 2276 patients with pituitary adenomas, surgically resected and conformed by pathology in our hospital from January 1997 to December 2013, were collected. In these patients, 181 were growth hormone (GH) adenomas, 391 were prolactin (PRL) adenomas, 75 were GH/PRL adenomas, 68 were adrenocorticotropic hormone (ACTH) adenomas, 32 were thyrotropic hormone (TSH) adenomas, 493 were follicle-stimulating hormone/luteinizing hormone (FSH/LH) adenomas, 866 were NULL cell adenomas, and 170 were plurihormonal adenomas; the clinicopathologic characteristics of these patients were retrospectively analyzed; the ki-67 index and incidence of stroke were compared between invasive pituitary adenomas and non-invasive pituitary adenomas.
ResultsThe percentage of patients with symptoms caused by mass effects (headaches, nausea/vomiting, vision loss, visual field defects and polydipsia polyuria) and hormone abnormality (acromegaly, amenorrhea, galactorrhea and Cushing syndrome) were 79.5% and 26.8%, respectively; endocrine symptoms were common in GH adenomas and PRL adenomas. PRL adenomas, ACTH adenomas and null cell adenomas had higher incidence of invasion among different types of pituitary adenomas. The ki-67 index was not statistically significant between invasive and non-invasive adenomas (2.4±2.2vs.2.1±2.0, P>0.05). The incidence of stroke was not statistically significant between invasive and non-invasive adenomas (9.4% vs. 9.3%, P>0.05).
ConclusionPituitary adenomas of different types have different clinical manifestations, and the clinical manifestations and pathological classification is not a one-to-one relationship; the proliferation and apoplexy features in invasive and non-invasive adenomas are not different.
Key words:
Pituitary adenoma; Immunohistochemistry; Invasion; Pituitary apoplexy
Contributor Information
Zhao Zhao
Graduate School, Tianjin Medical University, Tianjin 300070, China
Jin Shumei
Zhang Xuebin
Tang Fan
Yan Xuejiang
Xue Kai
Yan Xiaoling
Yao Xin