A predicting model for outcomes of subthalamic nucleus deep brain stimulation in Parkinson’s disease
Yang Lu, Chen Yao, Fengfei Lu, Longping Yao, Xusheng Hou, Haoyuan Wang, Xiaozheng He, Yongyi Ye, Xiang Sun, Jianguo Zhang, Shizhong Zhang
Abstract
ObjectiveTo establish a predicting model for the therapeutic outcomes of subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD) and explore the underlying effect of predictors on DBS outcomes.
MethodsA retrospective review of clinical data of 31 patients with PD who underwent STN-DBS in our hospitals from January 2013 to December 2013 was performed. Each follow-up as an observation value was integrated into the model. Correlation matrix was used to explore the relationship between each variable and clinical efficacy. Stepwise regression was used to establish a linear regression equation. The normality, variance, linearity and strong influence of the model were evaluated.
ResultsDisease duration, age, preoperative on-state duration, preoperative non-dyskinesia duration, mini-mental state examination scores, following up times, trajectory length through STN and total electric energy delivered were included in the prediction model, in which R2 was 0.433 and F value was 9.345 (P=0.000). The prediction model satisfied the linearity, homoscedasticity, outlier check and influential observation check.
ConclusionsOur model could effectively predict the therapeutic outcomes of STN-DBS in PD patients. This predicting model could serve as a reference for doctors and the future automatic post-DBS programming.
Key words:
Parkinson’s disease; Deep brain stimulation; Nubthalamic nucleus; Predicting model
Contributor Information
Yang Lu
Department of Neurosurgery, National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Chen Yao
Department of Neurosurgery, National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Fengfei Lu
Department of Neurosurgery, National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Longping Yao
Department of Neurosurgery, National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Xusheng Hou
Department of Neurosurgery, National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Haoyuan Wang
Department of Neurosurgery, National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Xiaozheng He
Department of Neurosurgery, National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Yongyi Ye
Department of Neurosurgery, National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Xiang Sun
Department of Neurosurgery, National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Jianguo Zhang
Department of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China
Shizhong Zhang
Department of Neurosurgery, National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
