Clinical Research
High frequency magnetoencephalographic signals in surgery of refractory temporal lobe epilepsy
Jie Wu, Yigang Feng, Pengfei Liu, Jialiang Tan, Xueqiang Yan, Dan Zhu, Jing Xiang
Published 2017-06-15
Cite as Chin J Neuromed, 2017, 16(6): 620-624. DOI: 10.3760/cma.j.issn.1671-8925.2017.06.016
Abstract
ObjectiveTo investigate the value of high frequency magnetoencephalography signals in the localization of refractory temporal lobe epilepsy.
MethodsRetrospective analysis was performed in 10 patients with refractory temporal lobe epilepsy admitted to and accepted surgery in our hospital from January 2015 to December 2015. Surgical approaches of these patients were determined according to the results of long-term video EEG monitoring (VEEG), MR imaging, and conventional and high-frequency magnetoencephalography (MEG). MEG positioning analysis was performed after the surgery; followed up for 12 months was performed to evaluate the surgical efficacies.
ResultsThe surgery was effective in all the 10 patients; 5 patients achieved Engel grading I, 2 patients achieved Engel grading II, and 3 patients achieved Engel grading III. The results of high-frequency MEG analysis indicated that 8 lesions were consistent with the surgical sites, enjoying good results; while the positioning error of the 2 patients was large.
ConclusionsThe localization analysis of high-frequency neuromagnetic signals has the potential to determine epileptogenic zones preoperatively for epilepsy surgery. High-frequency oscillation is a new biomarker for the diagnosis of epilepsy.
Key words:
High frequency signal; Magnetoencephalography; Epilepsy surgery; Temporal lobe epilepsy
Contributor Information
Jie Wu
Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou 510510, China
Yigang Feng
Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou 510510, China
Pengfei Liu
Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou 510510, China
Jialiang Tan
Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou 510510, China
Xueqiang Yan
Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou 510510, China
Dan Zhu
Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou 510510, China
Jing Xiang
Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati 45220, United States
