Glioma, especially glioblastoma, is one of the most common malignancies in the central nervous system. Traditional surgery combined with radiotherapy and chemotherapy did not significantly change the survival time of gliomas. Invasive growth, high heterogeneity and existence of glioma stem cell are the main causes of tumor recurrence. In addition, various immune cells and cytokines secreted by them in tumor microenvironment, as well as their activation status, are the key factors affecting tumor progress and effecacy of various immunotherapy. Interleukin (IL)-33 is a member of IL-1 gene family, and in recent years, it has been confirmed that IL-33 is highly expressed in some brain tumors, and IL-33 is the main coordinator of microenvironment regulation in brain tumors. In this paper, we will introduce the immunosuppressive state of brain tumors and their microenvironment and the limitation of tumor growth and immunotherapy, and recent advance that cytokine regulate and intervene the microenvironment of glioma to adapt tumor-lytic virus-immunotherapy.

Glioma; Interleukin-33; Glioma microenvironment; Oncolytic virus-immunotherapy