A Meta-analysis of microsatellite instability as a factor of prognosis and response to chemotherapy for colorectal cancer
XU Yan, WANG Sheng-qiang, LIAO Kai-you, WU Yi, MU Yan-fei
Published 2013-08-28
Cite as , 2013,25(08): 530-534. DOI: 10.3760/cma.j.issn.1006-9801.2013.08.008
Abstract
Objective To investigate the correspond of microsatellite instability (MSI) on the prognosis and the effect of chemotherapy for colorectal cancer.Methods The publications about the MSI of colorectal cancer from January 2011 to October 2012 were searched.The Web of Knowledge and MEDLINE (PubMed) databases were used for searching English articles.The CNKI and WanFang databases were used for searching Chinese articles.Statistical analysis and graphics were performed with Comprehensive Meta Analysis V2 software.Results Thirty papers were included in this study.For the prognostic Meta-analysis,MSI-H was a protective factor for the overall survival of patients (OR =0.634,0.558-0.720; P < 0.001).Simultaneously,MSI-H was a protective factor for the disease-free survival of patients (OR =0.571,0.479-0.681; P < 0.001).After using of 5-Fu,the survival rate of MSS/MSI-L patients could be significantly elevated (OR =0.515,0.433-0.611; P < 0.001).However,the survival rate of MSI-H patients did not increase significantly (0.631,0.302-1.318; P =0.220).Conclusions Both the overall survival and disease-free survival of MSI-H patients were significantly better than that of MSS/MSI-L patients.For MSS/MSI-L patients,the chemotherapy effect was remarkable.However,for MSI-H patients,there was no statistics difference between chemotherapy and no-chemotherapy group.
Key words:
Colorectal neoplasms; Microsatellite instability; Prognosis; Meta-analysis
Contributor Information
XU Yan
Department of Integrated, Chongqing Cancer Institute, Chongqing 400030, China
WANG Sheng-qiang
Department of Integrated, Chongqing Cancer Institute, Chongqing 400030, China
LIAO Kai-you
Department of Integrated, Chongqing Cancer Institute, Chongqing 400030, China
WU Yi
Department of Integrated, Chongqing Cancer Institute, Chongqing 400030, China
MU Yan-fei
Department of Integrated, Chongqing Cancer Institute, Chongqing 400030, China