Renal failure is a common feature of multiple myeloma(MM)that may provide a clue to diagnosis and cause a major management problem.Depending on the definition of renal failure,this complication occurs in 20%-40%of newly diagnosed patients with MM and part of patients with newly diagnosed MM have renal failure severe enough to require renal replacement with dialysis at the time of diagnosis,which affects the quality of their life.Recently many progress in this complication have made.This review will focus on the pathogenesis and treatment of renal failure in multiple myeloma.