Original Article
Clinical effect of iliac artery interventional chemotherapy combination with bladder perfusion for high level of bladder urothelial carcinoma
Jiansen Chen, Ming Li, Yueqing Wu, Mao Tang, Akberomer, Zetian Tang, Xinwu Guo, Jinqian Li, Kesong Qin, Jiwei Ye, Zhiyuan Ma, Yuanjing Shen, Ye Chen, Yuan Li, Sai Zhang
Published 2017-09-15
Cite as Int J Surg, 2017, 44(9): 583-586. DOI: 10.3760/cma.j.issn.1673-4203.2017.09.003
Abstract
ObjectiveTo evaluate the clinical effect of iliac artery interventional chemotherapy combination with bladder perfusion for high level of bladder urothelial carcinoma after transurethral bladder tumor electricity cut operation for those who intend to retain the bladder.
MethodsFrom February 2010 to December 2016, a total of 74 cases high-grade urothelial carcinoma of the bladder, giving chemotherapy and suitted support were retrospectively analyzed. The patients were divided into two groups according to different chemotherapy methods.Artery perfusion chemotherapy group: 43 cases treated by transurethral bladder tumor cutting + bilateral iliac artery interventional perfusion chemotherapy+ bladder perfusion in combination therapy; Intravenous chemotherapy group: 31 cases underwent transurethral bladder tumor cut method + cisplatin, vein gemcitabine + bladder perfusion chemotherapy combined therapy. According to the (±s) between the groups. The method of count data is represented by chi-square test. Kaplan-meier method was used to describe the survival time of two groups of patients after operation.
ResultsTwo groups of patients with postoperative there was no statistically significant difference in disease-free survival time.In the bone marrow suppression (χ2=4.956, P=0.029); gastrointestinal tract reaction(χ2=5.912, P=0.012); dermatitis, mucositis(χ2=4.276, P=0.013), etc., has the advantages in the iliac artery interventional perfusion chemotherapy (P<0.05).
ConclusionVia efficient iliac arterial infusion chemotherapy in patients with venous chemotherapy patients, to the retention of the bladder has a certain value, and the incidence of adverse reactions after surgery is low, have certain advantages.
Key words:
Urinary bladder neoplasms; Chemotherapy, cancer, regional perfusion; Case-control studies; Internal iliac artery chemotherapy; High level
Contributor Information
Jiansen Chen
Department of Urology, Nanyang Second General Hospital, Nanyang 473012, China
Ming Li
Yueqing Wu
Mao Tang
Akberomer
Zetian Tang
Xinwu Guo
Jinqian Li
Kesong Qin
Jiwei Ye
Zhiyuan Ma
Yuanjing Shen
Ye Chen
Yuan Li
Sai Zhang