Review
Current status and progress in the research for viral nfection-associated gastric cancer
Zhang Xinyang, Li Yuan, Zhang Zizhen, Zhao Enhao
Published 2019-04-15
Cite as Int J Surg, 2019,46(4): 254-261. DOI: 10.3760/cma.j.issn.1673-4203.2019.04.009
Abstract
Gastric cancer is one of the malignant tumors with high morbidity and high mortality in China. Research has shown that viral infection is closely related to the occurrence of gastric cancer. Epstein-Barr virus-associated gastric cancer characterized by EB virus infection has been classified as a subtype of gastric cancer, whose epidemiology, pathogenesis, clinical and histopathologic features have been studied in detail. At the same time, oncolytic viruses reveal the inhibitory effect of the virus on tumors, and their ability to target and kill tumor cells is used in the treatment of some advanced cancers. This article will review the research advances about relevance to gastric cancer of several viruses that have been reported and the latest progress in anticancer mechanisms and combined therapies for oncolytic viruses.
Key words:
Herpesvirus 4, human; Stomach neoplasms; Tumor virus infections; Correlation; Neoplastic processes; Oncolytic virus
Contributor Information
Zhang Xinyang
Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
Li Yuan
Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
Zhang Zizhen
Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200127, China
Zhao Enhao
Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200127, China
