Original Article
Analysis of blood arsenic concentration and safety of arsenic-containing compound Qinghuang powder in patients with myelodysplastic syndrome
Zhu Qianze, Deng Zhongyang, Wang Mingjing, Zhao Pan, Fang Su, Song Minmin, Wang Hongzhi, Yang Xiupeng, Xu Yonggang, Yi Bowen, Shang Xiaohong, Ma Rou, Hu Xiaomei
Published 2017-11-30
Cite as Int J Trad Chin Med, 2017,39(11): 976-980. DOI: 10.3760/cma.j.issn.1673-4246.2017.11.005
Abstract
ObjectiveTo analyze the blood arsenic concentration and the safety of compound Qinghuang powder (compound QHP) in patients with myelodysplastic syndrome (MDS).
MethodsA total of 45 MDS patients received treatment with compound QHP (the treatment group, n=45). The concentration of blood arsenic in different time was determined by atomic fluorescence spectrometry. The clinical safety of compound QHP was evaluated by analyzing the symptoms of adverse reaction and organ function. The comparison were MDS patients with Qinghuang powder (QHP group, n=47) and healthy people.
ResultsThere was no significant difference of the blood arsenic concentration between the treatment group and the healthy control group (P=0.450), while after the treatment for 1 month those concentrations significantly increased (P=0.000). There were no significant difference between the blood arsenic concentration after treatment for 1, 3, and 6 months (P=0.240). The incidence of adverse reaction in the treatment group was significantly lower than that in QHP group(χ2=4.720, P=0.030). The incidence of adverse reactions in the digestive tract was significantly lower in the treatment group than that in QHP group (χ2=4.650, P=0.034). The blood arsenic concentration of patients with abdominal pain diarrhea was significantly lower than those without abdominal pain diarrhea (P=0.020). Before treatment in the compound QHP group, there were 21 cases with increased myocardial enzymes, 10 cases with abnormal liver function and 4 cases with renal dysfunction, respectively. After treatment at 6th month, these indicators returned to normal with 7 cases of myocardial enzymes, 6 cases of liver function and 1 case of renal function, respectively. There was no new case with abnormal myocardial enzymes, liver function and renal dysfunction, respectively.
ConclusionsArsenic could be absorbed in the digestive tract into blood in MDS patients after treatment with arsenic-containing compound QHP, and the blood arsenic concentration remained stable during the course of treatment. The adverse reactions were mainly mild gastrointestinal symptoms, but no heart, liver or renal function damage was observed. The incidence of abdominal pain diarrhea in patients treated with compound QHP was significantly lower than that with QHP.
Key words:
Myelodysplastic syndromes; Realgar; Arsenicals; Patient Safety
Contributor Information
Zhu Qianze
Department of Hematology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China
Deng Zhongyang
Wang Mingjing
Zhao Pan
Fang Su
Song Minmin
Wang Hongzhi
Yang Xiupeng
Xu Yonggang
Yi Bowen
Shang Xiaohong
Ma Rou
Hu Xiaomei
