Experimental and Prescriptions of Chinese Medicine
Effect of Xiaoyaosan on sexual behavior and inflammatory factors of rat with depression
Liu Yueyun, Gao Jingjing, Zhao Xin, Yue Lifeng, Wang Gang, Yu Hairong, Wei Na, Ma Xin, Liang Yuan
Published 2019-11-30
Cite as Int J Trad Chin Med, 2019,41(11): 1208-1212. DOI: 10.3760/cma.j.issn.1673-4246.2019.11.013
Abstract
ObjectiveTo study the effects of Xiaoyaosan on sexual behavior and inflammatory factors of rat with depression.
MethodsThe establishing depressive rat models of chronic mild unpredictable stress were established. The rats were randomly divided into model group and Xiaoyaosan group, 15 in each group. The Xiaoyaosan group was given 4.612 5 g/(kg•d) Xiaoyaosan, the blank group and the model group were intragastrically administered with normal saline once daily. After 4 weeks of oral administration, mount frequency and perineal licking numbers to female rats in each experimental group were observed by sexual behavior experiment, and the spleen index and thymus index were calculated. The serum DA, IL-1β, IL-6 levels were tested by Elisa.
ResultsCompared with the normal group, the mount frequency (4.42 ± 3.91 vs. 11.58 ± 6.54), perineal licking numbers (3.53 ± 3.29 vs. 16.36 ± 10.68) and serum DA levels (14.14 ± 0.71 pg/ml vs. 17.44 ± 4.06 pg/ml) in the model group significantly decreased (P<0.05 or P<0.01), and the thymus index (0.012 4 ± 0.001 8 vs. 0.009 3 ± 0.001 7), serum IL-1β (39.45 ± 11.98 pg/ml vs. 28.62 ± 6.61 pg/ml), IL-6 levels (9.74 ± 1.49 pg/ml vs. 6.40 ± 0.66 pg/ml) significantly increased (P<0.05 or P<0.01). Compared with the model group, the contents of serum DA in Xiaoyaosan group (15.90 ± 1.24 pg/ml vs. 14.14 ± 0.71 pg/ml) increased significantly (P<0.01), and the thymus index (0.009 9 ± 0.001 3 vs. 0.012 4 ± 0.001 8) and IL-6 levels (8.32 ± 0.39 pg/ml vs. 9.74 ± 1.49 pg/ml) decreased significantly (P<0.05).
ConclusionsThe Xiaoyaosan had a therapeutic effect on immune dysfunction and increases the expression of serum dopamine in depressive rats, which may be one of the mechanisms of its anti-depression.
Key words:
Xiao Yao San; Chronic mild unpredictable stress; Depression; Interleukin-6; Interleukin-1beta; Dopamine; Rats
Contributor Information
Liu Yueyun
Academy of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Gao Jingjing
Master Degree Candidate in 2017, Institute of Basic Theory of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
Zhao Xin
Academy of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Yue Lifeng
The Third Department of Brain Deseases, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Wang Gang
Department of Peripheral Vascular Surgery, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Yu Hairong
Department of B-mode Ultrasound, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Wei Na
Department of B-mode Ultrasound, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Ma Xin
Department of B-mode Ultrasound, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Liang Yuan
Department of Magzine, Institute of Basic Theory of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
