Original Article
Clinical application value of prognostic nutritional index for predicting survival in patients with advanced colorectal cancer
Xin Yan, Lizhuo Wang, Yan Kong, Lixin Fan
Published 2018-04-05
Cite as Chin J Postgrad Med, 2018, 41(4): 293-296. DOI: 10.3760/cma.j.issn.1673-4904.2018.04.002
Abstract
ObjectiveTo explore the clinical application value of prognostic nutritional index (PNI) for predicting overall survival (OS) in patients with advanced colorectal cancer.
MethodsSeventy-two patients with histologically confirmed colorectal cancer were enrolled in this study, and their clinical and laboratory data were reviewed. The PNI was calculated, and univariate and multivariate analysis was used to identify the potential prognostic factors for advanced colorectal cancer.
ResultsPNI of the 72 colorectal cancer patients was 45.07 ± 5.98. PNI was significantly associated with age, weight loss and pleural effusion (P < 0.05). However, PNI showed no correlation with sex, clinical stage, smoking, bloody stool, abdominal mass, intestinal obstruction, histological type, radiotherapy and KPS scores (P > 0.05). The median OS of the 72 patients was 12.9 months. The medium OS in the higher PNI group (PNI ≥ 45.07) and lower PNI group (PNI ≤ 45.07) was 15.7 months and 11.2 months, respectively. The 1-year survival rates were 78.4% and 60.5%, and 2-year survival rates were 53.1% and 20.8%, respectively (P < 0.01). Univariate analysis showed that PNI, ages, and weight loss were related to the OS of the advanced colorectal cancer (P < 0.05). Multivariate analysis identified PNI was an independent prognostic factor for OS of advanced colorectal cancer (P < 0.01).
ConclusionsPNI can be easily calculated, and may be used as a relatively new prognostic indicator for advanced colorectal cancer in clinical practice.
Key words:
Advanced stage, colorectal cancer; Prognostic nutrition index; Prognosis
Contributor Information
Xin Yan
Department of Neoplasms, the Third People′s Hospital of Dalian, Dalian 116033, China
Lizhuo Wang
Yan Kong
Lixin Fan