Original Article
Correlation among fractional exhaled nitric oxide, child asthma control test, lung function and disease severity in children with asthmatic
Caihong Sun, Xiaomeng Liu, Yong Jiang, Jing Liu, Chong Wang, Zhaochuan Yang, Zhenghai Qu
Published 2019-08-05
Cite as Chin J Postgrad Med, 2019, 42(8): 682-685. DOI: 10.3760/cma.j.issn.1673-4904.2019.08.004
Abstract
ObjectiveTo investigate the correlation among fractional exhaled nitric oxide(FeNO), child asthma control test(C-ACT) and lung function in asthmatic children and its clinical significance.
MethodsA total of 108 cases of asthmatic children in the Affiliated Hospital of Qingdao University from June 2016 to September 2018 were recruited. Forty-seven cases (47.44%) were in acute onset, 40 cases(40.37%) were in chronic persistent, and 21 cases (21.19%) were in paracmasis. FeNO, lung function and C-ACT score were measured, and the correlation among them was analyzed.
ResultsThe level of FeNO in acute onset patients and chronic persistent patients had no significant difference: (44.18 ± 25.47) × 10-9 vs. (46.98 ± 27.50) × 10-9, P > 0.05, but the level of FeNO in paracmasis patients was lower [(24.43 ± 10.71) × 10-9], compared with that of acute onset patients and chronic persistent patients, there were significant differences (P < 0.01). The scores of C-ACT in three groups had significant difference (P < 0.01), and there were significant differences between any two groups (P < 0.01). The levels of forced expiratory peak flow rate measured value as a percentage of predicted value (FEV1%) and forced expiratory volume and forced vital capacity ratio in the first second (FEV1/FVC) in acute onset patients were significantly lower than those in chronic persistent patients and paracmasis patients (P <0.01), and there were no significant differences between chronic persistent patients and paracmasis patients (P>0.05).
ConclusionsCompared with lung functions and C-ACT, FeNO is a good biomarker to evaluate the airway inflammation of asthmatic children.
Key words:
Bronchial asthma; Child; Exhaled nitric oxide; Lung function tests; Asthma control test
Contributor Information
Caihong Sun
Department of Pediatrics, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
Xiaomeng Liu
Department of Pediatrics, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
Yong Jiang
Department of Pediatrics, Maternity and Child Health Care of Zaozhuang, Shandong Zaozhuang 277100, China
Jing Liu
Department of Pediatrics, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
Chong Wang
Department of Pediatrics, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
Zhaochuan Yang
Department of Pediatrics, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
Zhenghai Qu
Department of Pediatrics, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
