Review
Research advances in repair of growth plate injury
Xie Yangli, Tan Qiaoyan, Luo Fengtao, Li Can, Huang Junlan, Du Xiaolan, Chen Lin
Published 2020-01-15
Cite as Chin J Orthop Trauma, 2020, 22(1): 88-92. DOI: 10.3760/cma.j.issn.1671-7600.2020.01.016
Abstract
Growth plate, the developmental center of endochondral osteogenesis, can be divided morphologically and functionally into a resting zone, a proliferative zone, a prehypertrophic zone and a hypertrophic zone. Injuries to growth plate often lead to bone growth defects including limb length discrepancy and angulation deformity in children. Currently, their orthopedic corrective surgeries are invasive and limitedly effective and no effective biotherapy has been available. Previous studies on animal models of growth plate damage have investigated the related cellular and molecular events in the repair of damaged growth plates in the 4 distinct inflammatory, fibrogenic, osteogenic and remodeling phases. Related molecules involved in the regulation of the above processes, such as inflammatory cytokines tumor necrosis factor alpha, mitogenic platelet-derived growth factor and bone morphogenetic protein, are found to participate in the regulation of growth plate injury. Exploration of the mechanisms may provide new targets for biotherapy. In addition, development of cartilage tissue engineering, especially application of mesenchymal stem cells, also provides potential interventions for growth plate injury.
Key words:
Tissue engineering; Wounds and injuries; Bone marrow cells; Growth plate; Chondrogenesis
Contributor Information
Xie Yangli
Department of Wound Repair and Rehabilitation, Laboratory for Prevention and Rehabilitation of Military Training Related Injury, Center of Osteoporosis and Bone development, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China
Tan Qiaoyan
Department of Wound Repair and Rehabilitation, Laboratory for Prevention and Rehabilitation of Military Training Related Injury, Center of Osteoporosis and Bone development, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China
Luo Fengtao
Department of Wound Repair and Rehabilitation, Laboratory for Prevention and Rehabilitation of Military Training Related Injury, Center of Osteoporosis and Bone development, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China
Li Can
Department of Wound Repair and Rehabilitation, Laboratory for Prevention and Rehabilitation of Military Training Related Injury, Center of Osteoporosis and Bone development, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China
Huang Junlan
Department of Wound Repair and Rehabilitation, Laboratory for Prevention and Rehabilitation of Military Training Related Injury, Center of Osteoporosis and Bone development, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China
Du Xiaolan
Department of Wound Repair and Rehabilitation, Laboratory for Prevention and Rehabilitation of Military Training Related Injury, Center of Osteoporosis and Bone development, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China
Chen Lin
Department of Wound Repair and Rehabilitation, Laboratory for Prevention and Rehabilitation of Military Training Related Injury, Center of Osteoporosis and Bone development, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China
