Clinical Researches
Correlation between heme oxygenase-1 gene rs2071746 polymorphism and long-term outcome in patients with ischemic stroke
Cao Liping, Zhu Linfeng, Li Huajie, Ji Lei, Yue Chunxian, Wu Jian, Sheng Shiying, Lian Xuegan
Published 2019-05-28
Cite as Int J Cerebrovasc Dis, 2019,27(5): 343-347. DOI: 10.3760/cma.j.issn.1673-4165.2019.05.005
Abstract
ObjectiveTo investigate the association between heme oxygenase-1 (HO-1) gene rs2071746 polymorphism and long-term clinical outcome in patients with ischemic stroke.
MethodsBetween July 2015 and June 2017, consecutive patients with acute ischemic stroke admitted to the Department of Neurology, the Third Affiliated Hospital of Soochow University were enrolled prospectively. TOAST classification was performed for all patients. Genotyping of the HO-1 gene rs2071746 polymorphism was performed using a modified multiplex ligase detection reaction technique. The patients were followed up. The primary endpoint events included ischemic stroke, vascular death, and myocardial infarction. Multivariate Cox proportional hazard regression model was used to analyze the independent influencing factors for primary endpoint events.
ResultsA total of 1 698 patients with successful genotyping and follow-up information were enrolled. Genotyping showed that the frequency of rs2071746 A allele was 44.91%. They were followed up for 15.21±7.39 months, and 168 patients (9.89%) had primary endpoint events. The incidence of primary endpoint events in A allele carriers was significantly lower than that in non-A allele carriers (8.80% vs. 12.40%; P=0.018). Multivariate Cox proportional risk regression model showed that after adjusting for age, gender, hypertension, diabetes mellitus, smoking, alcohol consumption, and genotype, A allele was an independent protective factor for primary endpoint events in patients with acute ischemic stroke (hazard risk [HR] 0.693, 95% confidence interval [CI] 0.506-0.949; P=0.022). Subgroup analysis showed that carrying the A allele was an independent protective factor for primary endpoint events in patients with large atherosclerotic stroke (HR 0.651, 95% CI 0.425-0.997; P=0.048), while rs2071746 polymorphism was not associated with long-term outcome in other etiological subtypes.
ConclusionThe HO-1 gene rs2071746 A allele may be a protective factor for the long-term outcome in patients with acute ischemic stroke and large atherosclerotic stroke.
Key words:
Stroke; Brain ischemia; Heme oxygenase-1; Polymorphism, genetic; Prognosis; Risk factors
Contributor Information
Cao Liping
Department of Neurology, the Third Affiliated Hospital of Soochow University, Changzhou 213000, China
Zhu Linfeng
Li Huajie
Ji Lei
Yue Chunxian
Wu Jian
Sheng Shiying
Lian Xuegan
