Objective To observe the clinical effect of Intravenous-inhalation anesthesia using Sevoflu-rane combined with Propofol in infant undergoing ophthalmic operation. Methods 60 ASA Ⅰ～Ⅱ children aged from 3 to 11 months were selected and randomly divided into two groups: intravenous combined with inhalation anesthesia group (Ⅰ group) (n=30) and total intravenous anesthesia group (Ⅱ group) (n=30). Children in Ⅰ group were induced with sevoflurane(4～6%) and maintained with sevoflurane(1.5～2.5%) and propofol 4 mg/(kg·h) during surgery,while those in Ⅱ group were induced with midazolam 0.1 mg/kg,fentanyl 2 μg/kg, atracurium 0.5 mg/kg after ketamine 6 mg/kgintramuscular injection, and maintained with total intravenous anesthesia with propofol 4～6 mg/(kg·h) The HR,SpO2 and PETCO2 were measured at different time points and recorded the post operation complications. Results Compared with T1 point, the HR was lower and the difference was significant in Ⅰ group(P<0.05). When compared with Ⅱ group the period of revival was shorter and the rates of post operation complications were much lower in Ⅰ group(P<0.01). Conclusion The anesthe-sia method of Intravenous-inhalation combined with sevoflurane and propofol is an ideal method in infant under-going ophthalmic operation.