Objective To make a comparative study between the Liquid-based cervical cytology and the Papanicolaou stain cytology,to evaluate the sensitivity of Liquid-based cytology to cervical pathology screening and its clinical value.Methods To apply the cytological analysis on 511 patients in two ways by using the TBS standards to let the two results be analyzed and compared with each other.Results Among the patients who are abnormal both in the Liquid-based cytology and the Papanicolaou cytology,the positive rate of the Liquid-based cytology is obviously higher than the Papanicolaou cytology' s,compared to the tissue biopsy.Conclusion Liquid-based cytology has a higher sensitivity compared with Papanicolaou cytology.It be can able to enhance the rate of detecting,thus achieve the goal of early detection,diagnosis and treatment.