Objective Applying focal ischemia-reperfusion model of SD rat on the condition of hyperglycemia,through observing the state of neurologic impairment score, cerebral pathomorphology and infarction volume after focal ischemia-reperfusion damage in SD rat on the condition of hyperglycemia. Methods 36 healthy male SD rats(weight from 180 g to 220 g)with normal blood glucemia(＜6 mmol/1)were randomly divided into 2 groups: control group(n = 18) and flunarizine + hyperglycenia group(treatment group n = 18). Each group was divided into 3 subgroups according to reperfusion 3 h (n = 6) , 6 h (n = 6), 24 h (n = 6) after ischemia for 90 minutes. Compare the differences of neurologic impairment score, cerebral infarction volume and pathomorphology. Results There are great difference of the neurologic impairment score between the two groups, P ＜0. 05. The infarction volume in the treatment group was lower than that in the control group,P ＜ 0. 01. Cerebral tissue pathomorphology:In treatment group, the injury of cerebral tissue became serious with time went by, but compared with control group,the number of neuron which became degeneration and necrosis decreased, vacuolization and intertissue edema became relieved. Conclusion On the condition of hyperglycemia, pretreatment of aspirin and flunarizine hydrochlorid could decrease focal ischemia-reperfusion damage, relieve the neurologic impairment symptoms;reduce infarction volume,reduce the neuron degeneration,necrosis and tissue edma.