Objective To discuss the relationship and possible mechanism between serum uric acid level and renal injury in early stage in Monglian patients with essential hypertension.Methods The patients with high blood pressure were chosen as the subjets,which the Mongolian patients were 86 cases and Han 89 cases.They were separately detected UA in the method of urease and Cys-C,β2 m in the way ofturbidimetric immunoassay.The data concerned were compared with each other.Results In Mongolian patients group with highblood pressure,the rate of uric acid was (456.32 ±45.49) μmol/L;that of Han patients group was (385.30 ±37.85) μmol/L.The rate of uric acid between Mongolian group and Han group showed apparent difference(P ＜0.05).UA showed positive correlation with Cys-c (r = 0.714、0.694,P ＜ 0.05)while U A showed positive correlation with β2 m(r =0.624、0.526,P ＜0.05)in the Mongolian group and in the Han group.CCr showed correlation with UA、Cys-c、β2 m when CCr ＜ 50 ml/min,r was 0.72、0.68、0.75、0.65 respectively;CCr showed correlation with UA、Cys-c、β2 m when CCr was 50-80 mL/min,r was 0.75,0.73,0.70.CCr showed correalation with SCr,r was 0.55.Conclusion Those Mongolian patients with hypertension were more likely to show the symptoms of renal injury and metabolic disorder.