Objective To investigate the clinical safety and prognosis of laparoscopic pericystectomy in the treatment of hepatic cystic echinococcosis.Methods The clinical data of 21 patients with hepatic cystic echinococcosis who received laparoscopic pericystectomy at the First Affiliated Hospital of Xinjiang Medical University were retrospectively analyzed.Albendazole [10 mg/(kg · d)] was administered orally to all the patients 1 week before operation.All the patients were followed up via outpatient examination and phone call till June 2012.The rate of transfer to the open surgery operation time,volume of blood loss,duration of postoperative hospital stay,incidence of postoperative complication and recurrence rate were analyzed.Results According to the standard issued by the Informal Working Group on Echinococcosis,all the 21 patients were with type CE1 hepatic cystic echinococcosis.The cysts were in hepatic segments Ⅱ-Ⅲin 8 patients,and in hepatic scgmcnts Ⅳ-Ⅵ in 13 patients.The diameters of the cysts ranged between 3-12 cm,and the mean diameter was 7 cm.The operation time,volume of intraoperative blood loss and duration of postoperative hospital stay were (76 ±23) minutes,(110 ± 35) mL and (4 ± 1) days.There were no patients who received blood transfusion or be transferred to open surgery.Bile leakage was occurred in 1 patient and was cured spontaneously at postoperative day 10.All the patients were followed up for 15-60 months,and the median time of follow up was 1 g months.No recurrence was observed.Conclusion Laparoscopic pericystectomy is safe and feasible for the treatment of hepatic cystic echinococcosis.