Expression and clinical implications of RADIL gene in pancreatic cancer
HUANG Hao-jie, GAO Jun, DU Yi-qi, GONG Yan-fang, LV Shun-li, WANG Xiao-wei, XU Ai-ping, GAO Fei, LI Zhao-shen
Published 2010-11-20
Cite as Chin J Pancreatol, 2010,10(06): 424-426. DOI: 10.3760/cma.j.issn.1674-1935.2010.06.015
Abstract
Objective To investigate the RADIL mRNA expression in pancreatic carcinoma and to evaluate its clinical significance.Methods Fluoesecent quantitative PCR (FQ-PCR) was used to detect the RADIL mRNA expression in 40 patients with pancreatic carcinoma and adjacent tissue and in 5 healthy adult with normal pancreatic tissue and to observe its relationship with clinicopathologic parameters.Results RADIL mRNA was expressed in pancreatic carcinoma and adjacent tissue, as well as normal pancreatic tissue, and the relative expression was 2.263 ± 3.826, 5.425 ± 8.858 and 8.559 ± 4.214, respectively.There was statistically significant difference among the three groups (P <0.05 ).RADIL mRNA expression was closely related with the metastasis and differentiation grade ( r = -0.312 and -0.294, P < 0.05 ), however, it was not significantly related to tumor site, tumor size, CA19-9, TNM staging, sex and age.Conclusions RADIL gene may have an inhibitory effect on the pancreatic cancer.
Key words:
Pancreatic neoplasms; Small GTP binding proteins; Fluorescent quantitative PCR; RADIL genes
Contributor Information
HUANG Hao-jie
Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
GAO Jun
Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
DU Yi-qi
Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
GONG Yan-fang
Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
LV Shun-li
Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
WANG Xiao-wei
Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
XU Ai-ping
Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
GAO Fei
Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
LI Zhao-shen
Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China