Objective To explore the effect of comprehensive intervention technique in neuroses nursing.Methods 48 inpatient neuroses were randomly divided into observation group(drug treatment and comprehensive intervention technique)and control group(drug treatment),using self-rating anxiety scale(SAS)and self-rating depression scale(SDS)to evaluate clinical symptoms before and after 2 months treatment.Results Before treatment.SAS and SDS scores between two patient groups had no statistic difference(P>0.05),but after 2 months treatment.the observation group had lower SAS and SDS scores than the control group,the difference were obvious(P<0.05).Conclusions Comprehensive intervention technique was useful in neuroses nursing which can ameliorate depression and anxiety emotions,improve illness recover.