Objective To discuss normalized safety management of using narcotic and psychotropic drugs with high flow rate in large scale operating rooms.Methods The whole process of drugs using and management in every details were consummated by utilizing flow sheet with fineness management,and regulations were optimized gradually through quality control periodically.Results Safety management of using narcotic and psychotropic drugs in our anesthesia and operation center had been realized and got affirmations and high reputations in the inspections of hospital and entire army at different levels.Conclusions Normalized safety management of using narcotic and psychotropic drugs with high flow rate in large scale operating rooms could be realized efficiently by using flow-sheet with fineness management.