Objective To discuss the effect of Roy adaptation model on mental nursing of percutaneous coronary intervention (PCI) patients.Methods Totals of 100 cases were randomly divided into control group (n =50) and observation group (n =50).Control group received the routine psychological care,while observation group received the psychological nursing intervention according to Roy adaptation model that including 6 steps.Then,anxiety,depression score change and heart rate and systolic blood pressure and diastolic blood pressure and the change of physiological indexes were observed and compared before and after the intervention room.Results Before intervention,anxiety and depression scores,heart rate,systolic blood pressure between two groups were not found significant difference (t =1.21,0.97,1.06 ; P ＞ 0.05).After the intervention,the anxiety,depression scores in control group were higher than that of observation group [(41.95 ± 4.11) vs (33.27 ± 3.51),(58.59 ± 4.61) vs (47.08 ± 3.77)],and the differences were statistically significant (t =5.130,12.620 ; P ＜0.01),as well as the heart rate [(92.2 ±4.1) vs (80.2 ±5.3) bpm] and systolic/diastolic pressure [(120.4 ± 20.3) vs (105.9 ± 21.0) mm Hg,(71.5 ± 8.54) vs (63.7 ±13.2) mm Hg],and the differences were statistically significant (t =6.54,7.18,5.93 ;P ＜ 0.01).Conclusions Roy' s adaptation model of psychological nursing intervention can improve the adaptability of the patients with PCI,relieve patients' anxiety,depression psychology、maintain stable vital signs,ensure the surgery operation successfully completed,and improve patient' satisfaction.