Objective To discuss nursing experience of tumor patients during high-frequency thermotherapy.Methods The nursing of 488 cases of different types of tumor patients before,during and after the high-frequency thermotherapy was retrospectively reviewed.The contents of nursing included psychological nursing,safety education,condition observation,dietary guidance and skin care.All adverse events were noted and treated appropriately.Results All of 488 tumor patients were completed the high-frequency thermotherapy successfully.Thirty patients experienced minor anxiety,3 patients got induration of subcutaneous fat,2 patients suffered ambustion and 2 patients had fever,but all the side effects were recovered after proper treatment.Conclusions The nursing should be adjusted according to patients' condition of before,during and after thermotherapy,in order to make sure the therapy be safe and completed successfully.