Objective To analyze the ICU death patient monitoring time,to explore the impact factors of time monitoring and put forward nursing countermeasures ; To analyze the distribution of death time of the patients and make preventive measures.Methods The medical history and the data of 52 death patients from July 2011 to July 2012 were retrospectively analyzed.Results The incidence and mortality of nosocomial infection in the three groups patients including intensive care time ≤ 1 day,from 2 to 7 days and ≥7 days were different,and the difference was statistically significant (x2 =6.741,P ＜ 0.05).The longer intensive care time,the higher incidence and mortality of nosocomial infection.The death cases were similar in the day shift and night shift,and the difference was not statistically significant (P ＞ 0.05).The time of death focus on each class after hand-over 2 hours.Conclusions Managers should take effective measures to prevent the occurrence of nosocomial infection.To standardize access and exit in ICU and to control the residence time of ICU patients,so as to reduce the infection and mortality.In this study,the time of death was concentrated in the shift time,managers should take corresponding nursing countermeasures,increase the force of nursing,timely detect changes in condition,so as to reduce the patients' death.