To explore the clinical nursing of Methotrexate combined with Mifepristone in patients with ectopic gestation.

Totals of 128 patients with ectopic gestation were treated by Methotrexate combined with Mifepristone, and blood β-HCG level and lump diameter size were measured. The patients were given comprehensive nursing including psychology, diet and daily activities, disease observation, drug adverse reaction and discharge guidance.

The rate of successful treatment was 94.5% (121/128). The level of blood β-HCG and diameter of lump after 1 week were significantly smaller than those before the treatment (t=33.2, 8.9, respectively; P<0.05). The level of blood β-HCG after 2, 3, 4 weeks were significantly lower than those after 1 week (t=64.2, 78.3, 105.9, respectively; P<0.05). And the diameter of lump after 2, 3, 4 weeks were significantly smaller than those after 1 week (t=6.4, 7.5, 8.3, respectively; P<0.05). Five patients (3.9%) had gastrointestinal reaction, three patients (2.3%) had slightly elevation of transaminase and leucopenia, two patients (1.6%) had oral ulcer and bone marrow suppression. Those symptoms were disappeared after treatment.

During the treatment of ectopic pregnancy, patients should be given positive psychological care, close clinical nursing and disease observation to promote the rehabilitation of patients.

Ectopic gestation; Methotrexate; Mifepristone; Nursing care