Clinical Research
Systematic review of treatment effect of the traditional Chinese medicine compound based on astragalus and angelica on bone marrow suppression after chemotherapy
Xue Mengting, Hao Xiaobei, Shi Xuqin, Yang Min, Wang Qing, Chen Yujing, Pan Yalan, Xu Guihua
Published 2020-02-26
Cite as Chin J Mod Nurs, 2020,26(06): 773-778. DOI: 10.3760/cma.j.issn.1674-2907.2020.06.014
Abstract
ObjectiveTo systematically review the effects of the traditional Chinese medicine compound based on astragalus and angelica on bone marrow suppression after chemotherapy.
MethodsRandomized controlled trials (RCTs) about the traditional Chinese medicine compound based on astragalus and angelica for bone marrow suppression after chemotherapy for malignant tumors were retrieved from Cochrane Library, PubMed, Web of Science, CINAHL, OVID, SinoMed, CNKI, VIP, and Wanfang Databases. The search period was from the establishment of the database to September 2019. The literatures were screened and the data were extracted independently by two researchers and RevMan 5.3 was used for Meta-analysis.
ResultsTotally 15 RCTs were included, involving 1 019 patients. Meta-analysis results showed that there were statistically significant differences in peripheral blood leukocytes [SMD=1.32; 95% CI (0.76, 1.89) ; P<0.000 01], platelets [MD=25.05; 95% CI (8.00, 42.10) ; P=0.004], hemoglobin [MD=24.14; 95% CI (16.34, 31.94) ; P<0.000 01] and clinical symptoms [RR=1.38; 95% CI (1.25, 1.52) ; P<0.000 01] between the chemotherapy group, the chemotherapy combined with the western medicine group and the traditional Chinese medicine compound group.
ConclusionsThe traditional Chinese medicine compound based on astragalus and angelica can improve the level of peripheral blood cells, reduce bone marrow suppression, and improve clinical symptoms and quality of life of patients with cancer after chemotherapy. However, due to the low quality of the included literature and the large heterogeneity of some of the results, more rigorously designed high-quality RCTs are needed for further verification.
Key words:
Antineoplastic combined chemotherapy protocols; Astragalus; Angelica; Bone marrow suppression; Meta-analysis
Contributor Information
Xue Mengting
School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210046, China
Hao Xiaobei
School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210046, China
Shi Xuqin
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
Yang Min
School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210046, China
Wang Qing
School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210046, China
Chen Yujing
School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210046, China
Pan Yalan
School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210046, China
Xu Guihua
School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210046, China