Objective To explore the role of plasma in treatment of critical disease in children. Methods One hundred and twenty-four examples suffered from critical diseases treated by plasma were analysed. Results Eighty-three percent of 124 cases turn out PICU with stable condition in one week. Children who accept plasma treatment in 12 hours after admission had better curative effect than those accept plasma treatment over 12 hours(P＜0.01). No untoward effect caused by plasma infusion occurred. Conclusions Plasma infusion is safe and effective in treating pediatric critical disease, and can be used as one kind of basic method in pediatric rescue. Plasma treatment effect is better when use it as soon as possible.