Objective To investigate the effects and adverse reactions of blue-ray radiation therapy for treatment of neonatal jaundice. Methods The clinical datas of 78 cases of neonatal jaundice were collected,all patients were taken transcutaneous jaundice index(TCB),liver function test,and the results were analyzed. Results Seventy-eight cases of neonatal jaundice were treated with blue-ray radiation for 8-12 hours,once a day,for 3-5 days,and then the patients were cured and discharged. Conclusions The blue-ray radiation therapy is simple,safe,effective and has few adverse reactions,is one of the main measures for treating neonatal jaundice.