Objective To explore the effect of atorvastatin on the level of serum high sensitivity C-reactive protein (hs-CRP) and interleukin-6(IL-6) in patients with acute cerebral infarction(ACI). Methods Eighty patients with ACI were randomly divided into the atorvastatin therapy group(n=40) and the conventional therapy group (n=40). At the basic of conventional therapy, the atorvastatin therapy group was treated with atorvastatin 20 mg/d. Both groups were treated for 4 weeks. The levels of serum hs-CRP and IL-6 were measured and the scores of neurological deficit(NDS) were evaluated before and after treatment. A healthy control group which approximately matched the experimental group included 20 cases. Results The levels of serum hs-CRP and IL-6 in both two groups after 14 d treatment were significantly lower than those before treatment (all P<0.05), and the level of serum hs-CRP and IL-6 in atorvastatin therapy group was significantly lower than that in conventional therapy group (P<0.05). NDS of both groups after treatment were lower than those before treatment (P<0 05), and the scores of atorvastatin therapy group were significantly lower than those of conventional therapy group (P<0.05). Conclusions Atorvastatin can significantly decrease the level of serum hs-CRP and IL-6, and it can promote the neurological fuction recovery in the patients with ACI.